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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Vaclav Safranek | Win | 6-1, 6-4, 6-2 |
| Second Round | Andrey Rublev | Loss | 5-7, 6-7 (3-7), 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Feliciano Lopez | Win | 7-6 (7-5), 6-4 |
| Third Round | Juan Martin Del Potro | Win | 6-3, 7-5 |
| Quarterfinals | Yuichi Sugita | Win | 6-2, 6-1 |
| Semifinals | John Isner | Win | 7-6 (7-4), 7-6 (12-10) |
| Final | Nick Kyrgios | Win | 6-3, 7-5 |
| Coupe Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mischa Zverev | Win | 6-3, 3-6, 6-3 |
| Third Round | Robin Haase | Loss | 6-7 (3-7), 6-4, 1-6 |
| Citi Open | ||
| Surface: Hard | Date: Jul. 31 - Aug. 6 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kyle Edmund | Win | 7-5, 4-6, 6-3 |
| Third Round | Daniil Medvedev | Loss | 4-6, 2-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Diego Schwartzman | Win | 7-6 (7-4), 6-2, 6-2 |
| Second Round | Marcos Baghdatis | Win | 6-3, 6-2, 6-1 |
| Third Round | Dudi Sela | Win | 6-1, 6-1, 0-0 Retired |
| Fourth Round | Roger Federer | Loss | 4-6, 2-6, 4-6 |
| AEGON Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Ryan Harrison | Win | 6-3, 6-1 |
| Second Round | Julien Benneteau | Win | 4-6, 6-3, 6-4 |
| Quarterfinals | Daniil Medvedev | Win | 6-3, 3-6, 6-3 |
| Semifinals | Feliciano Lopez | Loss | 5-7, 6-3, 2-6 |
| MercedesCup | ||
| Surface: Grass | Date: Jun. 12 - Jun. 18 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jerzy Janowicz | Loss | 6-7 (4-7), 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Stephane Robert | Win | 6-2, 6-3, 6-4 |
| Second Round | Tommy Robredo | Win | 6-3, 6-4, 7-5 |
| Third Round | Pablo Carreno Busta | Loss | 5-7, 3-6, 4-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Juan Martin Del Potro | Loss | 6-3, 2-6, 3-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Philipp Kohlschreiber | Win | 7-6 (9-7), 6-4 |
| Second Round | Ivo Karlovic | Win | 6-3, 7-5 |
| Third Round | Dominic Thiem | Loss | 6-4, 4-6, 6-7 (9-11) |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 16 - Apr. 23 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jan-Lennard Struff | Loss | 6-4, 3-6, 2-6 |
| Grand Prix Hassan II | ||
| Surface: Red Clay | Date: Apr. 10 - Apr. 16 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tommy Robredo | Loss | 4-6, 6-1, 1-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Guido Pella | Loss | 3-6, 6-7 (4-7) |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mikhail Youzhny | Win | 6-4, 6-0 |
| Third Round | Jack Sock | Loss | 6-3, 3-6, 6-7 (7-9) |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Mischa Zverev | Win | 6-7 (4-7), 6-2, 6-4 |
| Second Round | Denis Istomin | Win | 7-6 (9-7), 6-1 |
| Quarterfinals | David Goffin | Loss | 4-6, 6-1, 3-6 |
| Garanti Koza Sofia Open | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jerzy Janowicz | Win | 4-6, 6-3, 7-5 |
| Quarterfinals | Viktor Troicki | Win | 6-3, 6-3 |
| Semifinals | Nikoloz Basilashvili | Win | 6-1, 6-3 |
| Final | David Goffin | Win | 7-5, 6-4 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Christopher O'Connell | Win | 7-6 (7-2), 6-3, 6-3 |
| Second Round | Hyeon Chung | Win | 1-6, 6-4, 6-4, 6-4 |
| Third Round | Richard Gasquet | Win | 6-3, 6-2, 6-4 |
| Fourth Round | Denis Istomin | Win | 2-6, 7-6 (7-2), 6-2, 6-1 |
| Quarterfinals | David Goffin | Win | 6-3, 6-2, 6-4 |
| Semifinals | Rafael Nadal | Loss | 3-6, 7-5, 6-7 (5-7), 7-6 (7-4), 4-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Steve Johnson | Win | 6-2, 6-3 |
| Second Round | Nicolas Mahut | Win | 6-2, 6-4 |
| Quarterfinals | Dominic Thiem | Win | 6-3, 4-6, 6-3 |
| Semifinals | Milos Raonic | Win | 7-6 (9-7), 6-2 |
| Final | Kei Nishikori | Win | 6-2, 2-6, 6-3 |
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