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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 28 |
| Round | Opponent | W / L | Result |
| First Round | JC Aragone | Win | 6-3, 6-3, 6-1 |
| Second Round | Ernests Gulbis | Win | 6-3, 7-5, 6-4 |
| Third Round | Borna Coric | Win | 6-4, 6-3, 6-2 |
| Fourth Round | Paolo Lorenzi | Win | 6-4, 6-3, 6-7 (4-7), 6-4 |
| Quarterfinals | Sam Querrey | Win | 7-6 (7-5), 6-7 (9-11), 6-3, 7-6(9-7) |
| Semifinals | Pablo Carreno Busta | Win | 4-6, 7-5, 6-3, 6-4 |
| Final | Rafael Nadal | Loss | 3-6, 3-6, 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alexandr Dolgopolov | Loss | 4-6, 6-7 (6-8) |
| Coupe Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Dudi Sela | Win | 6-3, 7-6 (7-1) |
| Second Round | Pablo Carreno Busta | Win | 6-3, 7-6 (8-6) |
| Third Round | Sam Querrey | Win | 6-4, 6-1 |
| Quarterfinals | Alexander Zverev | Loss | 5-7, 4-6 |
| Citi Open | ||
| Surface: Hard | Date: Jul. 31 - Aug. 6 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Malek Jaziri | Win | 6-4, 6-1 |
| Third Round | Dominic Thiem | Win | 6-3, 6-7 (6-8), 7-6 (9-7) |
| Quarterfinals | Yuki Bhambri | Win | 6-4, 4-6, 6-3 |
| Semifinals | Jack Sock | Win | 6-3, 6-4 |
| Final | Alexander Zverev | Loss | 4-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Fernando Verdasco | Win | 2-6, 7-6 (7-5), 7-6 (10-8), 6-3 |
| Second Round | Andreas Seppi | Win | 6-3, 7-6 (7-4), 6-3 |
| Third Round | Ruben Bemelmans | Win | 7-6 (7-3), 6-4, 7-6 (7-3) |
| Fourth Round | Sam Querrey | Loss | 7-5, 6-7 (5-7), 3-6, 7-6 (13-11), 3-6 |
| AEGON International Eastbourne | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Thomaz Bellucci | Win | 6-3, 6-1 |
| Second Round | Richard Gasquet | Loss | 4-6, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Malek Jaziri | Win | 7-6 (7-4), 6-3, 7-6 (7-4) |
| Second Round | Nick Kyrgios | Win | 5-7, 6-4, 6-1, 6-2 |
| Third Round | Kyle Edmund | Win | 6-7 (6-8), 7-6 (7-4), 5-7, 6-1, 6-4 |
| Fourth Round | Marin Cilic | Loss | 3-6, 0-3 Retired |
| Banque Eric Sturdza Geneva Open | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Paolo Lorenzi | Win | 7-5, 7-6 (7-1) |
| Second Round | Jared Donaldson | Win | 6-3, 6-7 (7-9), 6-2 |
| Quarterfinals | Kei Nishikori | Loss | 6-2, 4-6, 6-7 (6-8) |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 14 - May 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alexander Zverev | Loss | 4-6, 6-4, 4-6 |
| Millennium Estoril Open | ||
| Surface: Red Clay | Date: May 1 - May 7 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Salvatore Caruso | Win | 6-2, 6-3 |
| Second Round | Joao Domingues | Win | 5-7, 6-3, 7-5 |
| Quarterfinals | Richard Gasquet | Win | 6-2, 3-6, 7-6 (7-4) |
| Semifinals | Gilles Muller | Loss | 5-7, 4-6 |
| Barcelona Open Banco Sabadell | ||
| Surface: Clay | Date: Apr. 24 - Apr. 30 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Carlos Berlocq | Win | 2-6, 7-6 (7-4), 6-3 |
| Second Round | David Ferrer | Win | 6-3, 6-4 |
| Third Round | Rafael Nadal | Loss | 3-6, 4-6 |
| Fayez Sarofim & Co. US Men's Clay Court Championship | ||
| Surface: Clay | Date: Apr. 10 - Apr. 16 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Fernando Verdasco | Loss | 6-7 (4-7), 6-7 (4-7) |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Dusan Lajovic | Win | 6-2, 7-5 |
| Second Round | Kei Nishikori | Loss | 4-6, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Federico Gaio | Win | 6-1, 6-4 |
| Second Round | Steve Johnson | Loss | 4-6, 6-3, 6-7 (4-7) |
| Delray Beach Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 26 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Juan Martin Del Potro | Loss | 4-6, 4-6 |
| Memphis Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Damir Dzumhur | Loss | 7-6 (8-6), 6-7 (2-7), 4-6 |
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